Voiceover what i hope to do in this video is give ourselves an appreciation for the sodiumpotassium pump, and as the name implies, it pumps sodium and potassium, but it does it in different directions. In each cycle, three sodium ions exit the cell, while two potassium. The novel insights and hypotheses on the role of the pump in cardiac. This section contains many topics on biology and health sciences and each of these categories contain many free biology books and resources and these are highly beneficial for teachers and students of health and biology professionals. How a sodium potassium pump can maintain a voltage gradient across a cell or neurons membrane. This unbalanced charge transfer contributes to the separation of charge across the membrane. Not only does the sodiumpotassium pump maintain correct concentrations of. Looking for online definition of na or what na stands for.
Discusses an example of active transport in which membrane protein moves sodium and potassium ions against large concentration gradients. Carrier proteins can work with a concentration gradient during passive transport, but some carrier proteins can move solutes against. In this issue, dennis paul and colleagues document the novel role that na k. It works constantly in the background to maintain the intracellular and extracellular sodium and potassium ion concentrations and is therefore essential for electrical activity in nerve cells.
Some of the resources in this section can be viewed online and some of them can be downloaded. Computations based on detailed atomic models explain how the atpdriven sodiumpotassium pump avoids transporting the wrong type of. The sodiumpotassium pump goes through cycles of shape changes to help maintain a negative membrane potential. Astrocytes also need na, k atpase pump to maintain the sodium gradient as the sodium gradient maintains neurotransmitter reuptake. Gene organization, analysis of the sodium pump by molecular biology. Paul johns bsc bm msc frcpath, in clinical neuroscience, 2014. Active transport by atppowered pumps molecular cell biology.
The sodiumpotassium pump is an important contributer to action potential produced by nerve cells. Na is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms the free dictionary. Voltagesensitive na channels were activated by adding 10 5 m veratridine at time 0. Free biology books download ebooks online textbooks. In epithelia, in addition to the classical chaperone function of the. Active transport is the energyrequiring process of pumping molecules and ions across membranes uphill against a concentration gradient. For every atp molecule that the pump uses, three sodium.
A gradient is formed when you have an area of high concentration next to. Effects of veratridine and tetrodotoxin ttx on the content of na k atpase in avian myocytes in tissue culture. The sodiumpotassium pump is important in the movement of ions across cell membranes of muscle cells. Neurons need the na, k atpase pump to reverse postsynaptic sodium flux to reestablish the potassium and sodium gradients which are necessary to fire action potentials. Expression of functional nak atpase in insect cells using baculovirus. Pdf plasma membrane atpases are primary active transporters of cations that. Nak pumps function to create a gradient between na and k ions. To move these molecules against their concentration gradient, a carrier protein is needed. Voltage dependence of nak pump current in isolated heart. Atpase sodium potassium adenosine triphosphatase, also known as the na. By agreement with the publisher, this book is accessible by the search feature, but.